Wholesale Pure Natural Atractylodes Lancea Oil for Daily Chemical Industry Herb Extract Atractylis Oil
pisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) is the common cancer between male and female, especially in Thailand. Recent study exhibited that the ethanol extract of AL exerted an inhibitory effect on OV-induced CCA animal model without obvious toxicity through oral administration for 30 days according to the results from positron emission tomography-computed tomography and male Syrian hamsters [7]. In order to explore the effect of AL rhizome on gastrointestinal motility, the atropine-, dopamine-, and 5-hydroxytryptamine (5-HT)-treated mice were adopted in the study. The results exerted that 1 mg/kg extract could vitally suppress dopamine-induced gastric emptying and gastrointestinal motility decrease through intraperitoneal injection. The extract at the concentration of 1000 mg/kg could restrict atropine-induced small intestinal motility decrease, and the extract of 500 mg/kg dose could block 5-HT-induced gastric emptying and small intestinal motility decrease [8]. Additionally, AL exerted anti-gastric ulcer effect in the rat model through decreasing inflammatory mediators (i.e. tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), and prostaglandin E2 (PGE2) and increasing epidermal growth factor (EGF) and trefoil factor2 (TFF2) [9]. Soil-borne fungal pathogens reduced 30% yields of peanuts [10]. Recently, it was reported that intercropping with the peanuts, AL could also suppress soil-borne fungal diseases through the inhibition of Fusarium oxysporum growth [11]. Petroleum ether (PE) extraction from AL showed an inhibitory effect on BGC-823 and SGC-7901 human gastric cancer cells. PE fraction could induce apoptosis, cell cycle arrest, and mitochondrial transmembrane potential changes [12]. A recent report exerted that MeOH extract of AL could inhibit nitric oxide (NO) production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells and induce granulocyte-colony stimulating factor (G-CSF) secretion in murine normal colonic epithelial MCE301 cells. NO is a free radical [13]. The ethanol extract of AL exerted an essential inhibitory effect on lipase with the IC50 9.06 µg/mL in a human pancreatic lipase assay, and exhibited anti-obesity effect on a high-fat diet-induced obesity mice model at the high concentration of 500 mg/kg [14]. The water extracts from AL showed the antagonistic activity against serotonin receptors and an inhibitory effect on the selective 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced head-twitch response in mice [15]. Water extracts from AL reduced triptolide-induced toxicity through the down-regulation of the hepatic expression of CYP3A. In the meantime, AL could improve anti-inflammatory effects of triptolide. These findings suggested that AL could inhibit toxicity and increase therapeutic activity of triptolide through combination
